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This distribution indicates the presence of trace amounts of smaller species such as monomers and dimers as well as a broad range of larger oligomers which are likely to be rapidly interconverting

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After a dose-titration and dose-stable run-in period of up to 16 weeks and a 2-week placebo run-in period, patients with inadequate glycemic control (A1C 7.5% to 10.5%) were randomized to the addition of either 100 mg of JANUVIA or placebo, administered once daily