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On top of that, the SURPASS-3 MRI sub study showed that a substantial fraction of the lean mass lost on tirzepatide was intramuscular fat, not muscle tissue
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That includes the anti-inflammatory effect, the ability to reduce cell death and promote autophagy, and also its indirect effects through blood pressure, obesity, and glucose/lipid metabolism
Gastroenterology 85 , 11201130 (1983)
