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Dietary Adjustments: Eating smaller, more frequent meals and avoiding high-fat or spicy foods can help reduce gastrointestinal discomfort and insulin resistance. Hydration: Staying hydrated during your treatment is essential, especially if you experience gastrointestinal adverse events like vomiting or diarrhea. Daily Exercise: Consistent activity like walking, jogging, or resistance training can strengthen bones and counteract both fat accumulation and bone density loss

These agents work by stimulating insulin secretion in a glucose-dependent manner, suppressing glucagon release, slowing gastric emptying, and promoting satiety through central nervous system pathways

From the Incretin concept and the discovery of GLP-1 to Todays Diabetes Therapy

She was in pain, developing multiple flare-ups per month, and with no energy

Notably, metformin can directly upregulate GLP-1R expression in pancreatic cells 29,30,31
