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Mean weight reductions corresponding to each group are 4.1%, 5.3%, 7.1%, 2.7%, and 1.4%, respectively (90)

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First introduced in 1927, insulin shock therapy was devised by Manfred Sakel, an Austrian neuropsychologist, after he observed an improvement in the psychiatric condition of one of his patients with a morphine addiction when he recovered from a hypoglycaemic coma accidentally induced by too much insulin

Therefore, DPP-4 inhibitors may have pleiotropic effects