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In the future, the use of synthetic biology technology to introduce MOTS-c into probiotics to achieve its accurate and controllable expression is of great significance to human health and the prevention of various diseases ( Figure 2 )

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GLP-1 plays a critical role in regulating blood sugar levels by stimulating insulin secretion from the pancreas after meals, slowing gastric emptying, and reducing appetite

Intermittent fasting exerts beneficial metabolic effects on blood pressure and cardiac structure by modulating local renin-angiotensin system in the heart of mice fed high-fat or high-fructose diets

Effect of dapagliflozin on atrial fibrillation in patients with type 2 diabetes mellitus: insights from the DECLARE-TIMI 58 trial