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All agents were associated with higher proportions of patients achieving at least 5% and 10% weight loss compared with placebo
However, Tirzepatide (Mounjaro) and Semaglutide (Wegovy or Ozempic) can cause side effects, most commonly gastrointestinal
10.1038/oby.2009.301 379
A subsequent analysis of SELECT trial data presented at the 2025 European Congress on Obesity found that the heart benefits appeared within just a few weeks of starting the medication and were not entirely explained by weight loss alone
