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Additional hypotheses include the rapid correction of glycemia following GLP-1 RA administration, similar to the exacerbation of DR, as well as long-term effects of prior hyperglycemia via persistent changes in endothelial gene expression, often referred to as glucose memory [198,199]

In some cases, combining medications (like GLP-1 + metformin or an SGLT2 inhibitor) can offer added benefits

1,3,5 Diabetes-focused studies increasingly support such stratified algorithms as cost-effective strategies to improve detection of advanced fibrosis

Reitman, Andrew Lutas & Michael J