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Clinical evidence from the STEP trials demonstrated that semaglutide users lost significantly more weight than those on placebo, with sustained results over 68 weeks

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Stenlf K, Cefalu WT, Kim KA, et al

Neuroimaging data further indicated that carriers of the 168Ser allele displayed enhanced blood oxygen leveldependent activation in the globus pallidus during feedback-related reward processing, suggesting altered reinforcement sensitivity within basal ganglia circuits [73]
