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No difference in total endogenous GLP1-levels during the OGTT was observed between the treatment groups when comparing either the curves ( Figure 1A ) or the area under the curve (AUC) ( Figure 2A )

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Berberine appears to increase GLP-1 by: Activating bitter taste receptors (TAS2Rs) that trigger the PLC (phospholipase C) signaling pathway in L-cells, which secrete GLP-1 Feeding beneficial bacteria in the gut that then produce short-chain fatty acids (SCFAs), which stimulate L-cells to secrete GLP-1 Gut microbiome health Berberine influences the gut microbiome, Agha-Khan says

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Another group contained nearly 19,000 older adults receiving non-GLP-1 drugs for type 2 diabetes