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The difference comes from tirzepatide's dual GLP-1/GIP receptor activation, which suppresses appetite more effectively than GLP-1 alone

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These symptoms may extend beyond mild discomfort and lead to severe secondary complications, including surgical site bleeding and elevated intraocular or intracranial pressure, thereby warranting particular caution during ophthalmic or neurosurgical procedures [38,39].Second, delayed gastric emptying can alter the absorption of orally administered medications, resulting in unpredictable pharmacologic responses to premedication before anesthesia [40]