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This two-pronged approach makes it a powerful tool for individuals struggling with obesity, insulin resistance, or stubborn weight loss

Insulin resistance plays an important role in the pathophysiology of comorbid T2DM and depression and can be a trigger for dysregulation of insulin- and GLP-1-mediated signaling (both central and peripheral), neuroendocrine disorders (hypothalamicpituitaryadrenal system dysfunction and monoaminergic neurotransmission disorders), chronic low-intensity inflammation, oxidative stress, and disorders of the microbiota-gut-brain system, reducing the level of neurotrophic factors in the brain and changing synaptic plasticity

Gail Brenner

Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: a systematic review and meta-analysis