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GLP-1 receptor agonists mimic or enhance the action of glucagon-like peptide-1, an incretin hormone involved in post-meal glucose control, insulin secretion, glucagon suppression, gastric emptying, appetite, and satiety

Physical activity progression should be individualised and gradually increased

Mayo Clinic recommends choosing a weight or resistance level heavy enough to tire your muscles after about 12 to 15 repetitions. Try this session 23 times per week with rest days between strength workouts: Warmup 3 to 5 minutes of easy movement Goblet squat 1 set of 1215 reps Dumbbell row 1 set of 1215 reps per side Incline push-up 1 set of 1215 reps Glute bridge 1 set of 1215 reps Plank 20 to 40 seconds Cooldown 2 to 3 minutes of breathing and mobility You can save this workout structure as a go-to routine, adjusting the resistance, repetitions, or rest times as your baseline strength improves over the 6-week cycle

Ensure complete emptying

Of particular interest to researchers is Retatrutides triple agonist mechanism, which published Phase 2 data suggests produces distinct and potentially additive metabolic effects compared to both selective GLP-1 agonists and dual GIP/GLP-1 agonists