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We therefore investigated the predictive value of these variables in our cohort, after adjusting for the non-genetic factors described above (Supplementary Information)

In other words, it is difficult to prove that these medications provide a direct benefit, rather than a secondary benefit from either weight loss or control of diabetes. He said more research is needed to determine if and how GLP-1 drugs can cause mood disturbances

This study suggested that GLP-1s might help prevent uric acid stones specifically, regardless of how much weight a person loses

Beyond absolute oxidative rate, mitochondrial resilience depends on spare respiratory capacitythe difference between basal and maximal electron transport fluxwhich reflects the ability to accommodate additional energetic demand without redox disequilibrium [64, 65]

While neither medication has demonstrated cardiovascular benefit in dedicated outcome trials yet, Mounjaros longer clinical experience provides more confidence regarding safety in this population