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It does this by copying the action of the hormone glucagon-like peptide-1, or GLP-1, which helps regulate appetite and food intake.Further studies examining the safety and effectiveness of the higher dose are already in progress

Int Immunopharmacol 143:113499 Yang S et al (2024a) Tirzepatide shows neuroprotective effects via regulating brain glucose metabolism in APP/PS1 mice

In clinical trials, the most common observations were gastrointestinal effects: nausea (44.2% vs 17.4% placebo in STEP 1), diarrhea (30.0%), vomiting (24.8%), and constipation (24.2%)

However, the SURMOUNT-5 trial compared tirzepatide to semaglutide 2.4mg (a more potent GLP-1 agonist than liraglutide), and tirzepatide still showed superior weight loss: 20.2% vs 13.7% at 72 weeks

However, if you experience severe vomiting or diarrhoea, additional contraceptive precautions may be advisable