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Limitations & Considerations The enrolled participants with obesity and overweight may represent a subpopulation with a greater commitment to weight-management efforts than the general population with obesity The measured baseline cardiometabolic risk factors in the trial population, such as blood pressure and lipids, were relatively normal, possibly attenuating the potential to show improvement, though meaningful changes in these variables were observed

Men lose weight faster in absolute terms early in treatment but show more variable long-term maintenance

Tirzepatide supports a gradual and sustained trajectory of weight loss, with the most significant reductions typically occurring in the initial months of treatment

Third, side effects are manageable and not interfering with daily life

this is my 3rd week and I have lost 6 lbs