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Description
The FDA prescribing information for Wegovy (semaglutide 2.4mg, the weight loss formulation) states that oral contraceptives should be used with a backup method for four weeks after starting semaglutide and for four weeks after each dose escalation

In some patients, gastrointestinal side effects can be severe enough to lead to treatment discontinuation

Factors that can cause IBS flare-ups include alteration in the gastrointestinal (GI) tract motility (or muscular action) abnormal nervous system signals increased sensitivity to pain food intolerances food allergies gastroenteritis (stomach flu or stomach bug) psychological conditions such as anxiety or depression hormone or neurotransmitter imbalance hormone imbalance gut infection gut dysbiosis increased intestinal hyperpermeability (leaky gut) small intestinal bacterial overgrowth (SIBO) IBS Diagnosis Since IBS is a collection of symptoms rather than a specific condition, no lab tests can diagnose it

Beginning July 1, 2026 , a new federal initiative called the Medicare GLP-1 Bridge Program will allow individuals enrolled in a Part D plan to access certain highly sought-after weight-loss drugs for a flat copay of $50 a month

VSMF: vascular smooth muscle fiber
