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Kohrt recommends women get a bone density scan before starting a GLP-1, especially since current screening guidelines don't recommend routine osteoporosis checks until age 65, which she says may be too late given how many younger women are now on the drugs

Looking toward the future, one has only to look at www.ClincalTrials.gov to see the many studies underway and planned for these drugs

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Tirzepatide at doses of 10 and 15 mg resulted in a decrease in the total number of LDLP compared to the placebo

At the time studies had indicated that glucagon acted on the GLP-1r only at pharmacological concentrations (223) although other data suggested a more complex relationship and that glucagon could act on both glucagon and GLP-1r to regulate insulin secretion (155)