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GLP-I(1-37) had no effect on insulin secretion even at concentrations as high as 5 X 10(-7) M

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Since most glucose-dependent insulinotropic polypeptide (GIP) receptor: glucagon-like peptide- 1 receptor (GLP- 1) receptor: glucagon receptor triagonists compete in efficacy with bariatric surgery, the success of these agents in preclinical models and clinical trials suggests a bright future for multi-agonists in the treatment of metabolic diseases

The study also found no increased risk of hospitalization for diabetic ketoacidosis or severe hypoglycemia, supporting further randomized trials of GLP-1RAs as adjunctive therapy in type 1 diabetes.

The landscape of weight management has expanded with new research shedding light on hormones like GLP-1 (glucagon-like peptide-1) and innovative supplements like Curb by Modere