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Immediate clinical attention is needed, and dose adjustment or discontinuation should be discussed urgently

What GLP-1 Medications Do In the Body (How They Work) GLP-1 (which stands for glucagon-like peptide-1) is a hormone released by the intestines after eating

However, GLP-1 drugs are not yet approved as standard dermatological treatments

Although the primary biological actions ascribed to intact GLP-1 are mediated by a single GLP-1 receptor [28], GLP-1 is rapidly cleaved by the enzyme dipeptidyl peptidase-4 (DPP-4) into GLP-1(9-36) [29], which exhibits its own biological activities (albeit not insulin secretion any more) [30,31], and thus intact GLP-1 exhibits a short half-life of one to two minutes in the circulation [32]

In these situations, dosing can vary from one fill to the next, making safe titration impossible