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Despite improved cardiovascular outcome associated with glucagon-like peptide 1 receptor agonists (GLP-1 RAs), they increase resting heart rate, the mechanism of which remains unclear

The microbiome enters the picture because those cells respond to short-chain fatty acids, which are made by gut bacteria fermenting fiber and mucin

This helps regulate blood sugar, reduce cravings, and support long-term weight loss and energy balance

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Scrocchi et al., 1996), this mechanism propelled the development of GLP-1 receptor agonists (GLP-1RAs), initially approved for diabetes (2005) and later for obesity (2014) (Jastreboff and Kushner, 2023)