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Description
Topline results from the ESSENCE trial demonstrated that 62.7% of patients who received once-weekly Wegovy 2.4 mg SC had improved steatohepatitis and 37% had improved liver fibrosis compared 34.1% and 22.5%, respectively, of patients who received placebo
These strategies involve the use of either DPP4-resistant synthetic analogues of GLP-1 (termed GLP-1 mimetics) or DPP4 inhibitors
Only one case in the literature reports the use of liraglutide to treat T2DM in a patient with HHD
73,74 The anti-fibrotic effects of DPP4 inhibitors such as vildagliptin and sitagliptin have been demonstrated in a mouse model of bleomycin-induced skin fibrosis, characterized by improved dermal texture, reduced hydroxyproline content, and decreased myofibroblast deposition through the inhibition of TGF--induced ERK signaling
Avoid lying down immediately after eating, and stay away from greasy, fried, or very spicy foods as they can worsen symptoms
