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MRGPRX2 receptor: Drug reactions Mast cells can be activated by IgE antigens in typical allergic reactions

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Even intravenous administration of GLP-1 at a physiological postprandial dose of 0.3 pmol/kg/min significantly slowed the rate of gastric emptying in healthy subjects, bringing them into a state of gastroparesis (Little et al., 2006)
Standard dosing regimens were derived from extensive trials to maximize efficacy while managing side effects