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This was despite the fact that the work behind the patent, filed in 1997 and granted in 2001, demonstrated that the peptide helped to lower body weight for four weeks in type 2 diabetes patients who were obese (DiMarchi, Efendic)

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The clinical research and emerging data on tirzepatide-based compounds, including GLP-1 GIP B12 formulations, point to a range of metabolic, cardiovascular, and anti-inflammatory benefits that extend well beyond the number on the scale

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[DOI] [PMC free article] [PubMed] [Google Scholar] 27.Hernandez N.S., ODonovan B., Ortinski P.I., Schmidt H.D