semaglutide for type 1 diabetes Ozempic® (semaglutide) GLP-1 RA 2 Increase in people using weight

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A clinical trial found that weekly doses of semaglutide a medication typically prescribed to Type 2 diabetes patients improved blood sugar levels and weight loss for adult Type 1 diabetes patients.

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Purpose of Review: This article summarizes the medical management of obesity with an emphasis on incretin-based therapeutics that target the neuro-hormonal basis of obesity.Recent Findings: Medications that mimic the effect of incretins, a group of peptide hormones released in response to nutrient intake that regulate appetite, result in potent and durable weight loss

Here, the authors report cryo-EM structures of tirzepatide-bound GIPR and GLP-1R, peptide 20-bound GIPR, GLP-1R and GCGR, revealing the molecular basis of their multiplexed pharmacological actions.