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The researchers found that nearly four percent of GLP-1 users developed osteoporosis, putting them at nearly a 30 percent higher risk compared to people who did not take the drugs

Research 13 also indicates that GLP-1 medications reduce the activation of appetite- and reward-related brain regions, such as the insula and amygdala, thereby reducing food intake

RSC Advances, 10, 80448053

Studies indicate that 86% of GLP-1 users do not meet daily protein requirements, consuming approximately 40g less protein than needed to preserve muscle mass

Glucagon-stimulation of insulin secretion is preserved in islets isolated from -cell-specific GCGR KO mice but is attenuated upon treatment of these islets with exendin (939) [173]