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Retrieved 23 March 2024

In a once-daily multiple ascending dose phase Ib clinical trial and a 41-day phase IIa trial in overweight and type 2 diabetic patients, general safety and tolerability of MEDI0382 were established, as well as placebo-corrected efficacy in reducing fasting blood glucose (1.7 mmol/L), post-prandial glucose excursions following a mixed meal test (22.6% AUC 04 h ), body weight (2.1 kg), and liver fat (19.6%) [7]

Analytical methods such as the Reporting Odds Ratio (ROR), Proportional Reporting Ratio (PRR), Bayesian Confidence Propagation Neural Network (BCPNN), and Empirical Bayesian Geometric Mean (EBGM) were employed to assess AE risk

This can include: Nausea: Many patients experience nausea when they first start taking GLP-1 drugs

Oh, I know all about the "allied comorbidities", who hasn't, but haven't seen an OS yet, unlike Keytruda, but remember, even here it's only in a subgroup of PD-1(+)