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A 2022 review in Gastroenterology looked at GLP-1 agonist use across multiple trials and found a roughly two-fold increase in acute pancreatitis risk compared to placebo

This makes it easier to eat less without constantly feeling hungry

This new medicine, generically called orforgipron, is a big win for Eli Lilly, potentially unlocking a worldwide market of millions more patients who want the convenience of a daily pill they can slot into their existing medicine regimen, at any hour of the day

When butyrate binds to free fatty acid receptor 2 (FFAR2) and free fatty acid receptor 3 (FFAR3) on intestinal L cells, it stimulates GLP-1 release

This finding may relate to the different abilities of these agonists to target brain regions that are crucial for memory processes (Salinas et al., 2018)