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GLP-1 receptor agonists like semaglutide mimic the effects of GLP-1, a hormone that is released after meals to signal satiety and reduce food intake

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Impact of Increased Residual Gastric Content on Clinical Consequences By increasing the risk of RGC, the use of GLP-1 RAs can have negative clinical consequences on patient outcomes

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The most concerning issue raised by the Phase 3 results was tolerability, particularly at higher doses