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Research published in BioScientifica confirms that GLP-1 receptors are located directly in the Ventral Tegmental Area (VTA) and the Nucleus Accumbens the parts of the brain that control wanting and craving. By dampening the dopamine hit we get from a binge, these medications can effectively decondition the brains reliance on food for pleasure

Notably, nutrient infusion directly into the duodenum at the same rate and volume in rats that had sham or VSG procedures caused similar increases in plasma GLP-1 (46)

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Fifty years of the mitochondrial pyruvate carrier: new insights into its structure, function, and inhibition