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If patients have a severe obesity-related complication including but not limited to hypertension, type 2 diabetes, CVD, dyslipidemia and a BMI of 27 mg/kg 2 or greater, then concurrent initiation of weight-loss medication with lifestyle interventions can be considered, according to the guideline

If hunger feels out of control or weight loss has stalled, it may be time to look deeper at how diet influences this hormoneand when to seek medical guidance

In the case of GLP-1 drugs, the most likely exemption could be for diabetes

The limited treatment landscape has created significant interest in repurposing existing drugs, particularly glucagon-like peptide-1 (GLP-1) receptor agonists, which address multiple metabolic pathways implicated in fatty liver disease

In early 2025, Pfizer scrapped its own experimental obesity pill (an oral GLP-1 candidate) due to safety concerns ( [35] ) ( [8] )