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2.6 Rapid Weight Loss and Lean Mass Weight loss induced by GLP-1 therapy includes both: Fat mass Lean mass Clinical trials suggest approximately 2040% of weight lost may consist of lean tissue if adequate protein intake and resistance training are not maintained. Reduced lean mass and inadequate protein intake may indirectly influence: Iron status Zinc intake B vitamin intake This secondary pathway reduced dietary density during rapid weight loss is a central nutritional consideration and will be explored in detail in the next section

Their close association with circulating markers of lipid metabolism and insufficient hepatic regeneration after liver surgery suggest a critical involvement during these processes in humans

How can clinicians improve long-term tolerability of GLP-1 medications

With its track record for efficacy and transformative outcomes, it's a pinnacle of obesity treatment that warrants serious consideration

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