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This paper introduces an AI-driven pipeline for efficient de novo design of peptide drugs, focusing on GLP-1 receptor agonists (GLP-1RAs) with extended half-life and enhanced efficacy
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In animal models of diabetes, the authors show that co-administration of a lipid-lowering drug with a dipeptidyl peptidase-4 inhibitor or a glucagon-like peptide-1 agonist improved glucose tolerance and beta cell mass
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