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These results prompted the hypothesis on a direct role of GLP-1 in controlling pubertal development through the hypothalamic GnRH secretion, although this mechanism still remains to be unraveled

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In summary, in this 26-week dose-finding study, oral semaglutide demonstrated robust efficacy for A1C reduction and weight loss, with the 20 mg and 40 mg once-daily doses of oral semaglutide producing similar glycemic and weight benefits when compared with injectable semaglutide

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