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This was the first cardiovascular outcomes trial in obesity (rather than diabetes) and established GLP-1 agonist benefit independent of glucose-lowering effects

A smaller percentage (29%) experienced mental side effects such as brain fog, mood swings, or anxiety
In 2020, Darzalex Faspro (Daratumumab and hyaluronidase-fihj) subcutaneous injection was approved for marketing, reducing the administration time from several hours with intravenous (IV) injection to 3-5 minutes with subcutaneous (SC) injection

We will also discuss how modern tools, including GLP-1 medications, can help manage these cravings effectively
1298A (leading to a Glu at amino acid 429) is the most common while 1298C (leading to an Ala substitution at amino acid 429) is less common
