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For someone with pancreatitis history, the risk is acute pancreatic inflammation

[114] randomized subjects to semaglutide or placebo to observe the change of liver fat from baseline to week 48, and found that semaglutide significantly reduced hepatic steatosis, improved liver enzymes and metabolic parameters, and had a positive effect on the diagnosis and treatment of NAFLD compared with placebo

Patients should seek medical advice for persistent vomiting, severe abdominal pain, signs of hypoglycaemia, or symptoms of pancreatitis

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For example, epigenetic diets rich in bioactive compoundssuch as sulforaphane, genistein, Epigallocatechin gallate(EGCG), resveratrol, and vitamin Ccan beneficially modulate sperm epigenomes and protect against environmentally induced abnormalities [104, 105]