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In the first phase, the mice were randomly placed into the water from one of the four quadrants each day to search for an underwater escape platform, and the time taken by the mice to swim to and find the platform served as the escape latency period

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When medication is appropriate, NICE recommends single-agent therapy with drugs licensed in the UK, such as orlistat (a lipase inhibitor) or, more recently, GLP-1 receptor agonists like semaglutide for eligible patients