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Consistent with these effects, GLP-1 RAs have been associated with substantial weight loss in clinical trials, leading to FDA approval of two of these agents liraglutide and semaglutide for chronic weight management in adults with obesity or with overweight and at least one weight-related comorbidity

Cost Impact and Equity of Access The high cost of GLP-1RAs presents a significant barrier to widespread access, especially in LMICs

We saw hashtags like #OzempicJourney and #SkinnyTok, discussions of Ozempic face, a flood of transformation photos and videos, and a bombardment of personal experiences that were usually framing these drugs as one size fits all

Fewer Comorbidities Affecting Capability People with diabetes are more likely to suffer from peripheral neuropathy (29.1% of T1D, 42.2% of T2D) and retinopathy (28.4% of T1D, 23.8% of T2D),14 among other things