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Early detection of diabetic nephropathy in patient with type 2 diabetes mellitus: A review of the literature

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Hyperglycemia alters both extracellular and intracellular metabolism, leading to effects such as glomerular hyperfiltration (4), oxidative stress (5), the accumulation of advanced glycation end products (AGEs) (6), the activation of protein kinase C (7), abnormal polyol metabolism (8), the overexpression of transforming growth factor- (TGF-) (9) and inflammation

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But they may last for up to 20 weeks if you titrate up to the highest dosage of Wegovy