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For glycemic control in type 2 diabetes, measurable reductions in hemoglobin A1c typically become apparent within 4-8 weeks, with maximum effects often seen at 12-16 weeks

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One conceived in the wake of recombinant DNA technology in the 70s, shaped by early anglerfish experiments in the 80s, and given further structure by elegant biochemical studies of GPCR signaling in the 90s
