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In the majority of the trials, the primary composite CV endpoint was a three-component major adverse CV event (MACE) outcome including CV-related mortality, non-fatal myocardial infarction (MI), and non-fatal stroke (the CVOT investigating lixisenatide, the ELIXA trial, also included time to the first occurrence of hospitalisation for unstable angina pectoris)

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and (3) dose escalation leading to gastrointestinal toxicity and prohibitive manufacturing costs before therapeutic efficacy is achieved

While obesity is consistently associated with reduced fertility and adverse reproductive outcomes in spontaneous conception, its impact in the setting of assisted reproductive technology (ART) appears to be more heterogeneous [7]

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