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When used in combination with intensive lifestyle modifications, the average weight loss with Contrave increased to more than 11% of their starting body weight, compared to 7% who took a placebo
Hyperglycemia-mediated cardiomyocyte damage is associated with inflammation

Direct comparison between medications requires understanding that trial designs, patient populations, and follow-up periods differ

According to the UK SmPC for Wegovy, fatigue is classified as a 'common' side effect (affecting between 1 in 10 and 1 in 100 people)

In contrast, participants without the risk allele showed correlations in the opposite direction (Karra et al., 2013)
