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Description
An important mediator in the process of reduced feelings of hunger is the hormone leptin, which, in interaction with GLP-1, regulates satiety and controls reward and aversion, suppressing hunger by inhibiting the appetite inducers AgRP/NPY neurons, while stimulating the satiety inducers POMC neurons [17,118,119]
The global, regional and national burden of type 2 diabetes mellitus in the past, present and future: a systematic analysis of the Global Burden of Disease Study 2019
Common Side Effects: Serious side effects include sedation, fatigue, and psychosis
doi: 10.1007/s40262-022-01140-3 [DOI] [PMC free article] [PubMed] [Google Scholar] 188.Frias JP, Nauck MA, Van J, et al
The dark blue circles in the terminal portion of tirzepatide are amino acids from exenatide, a protein-derived peptide (exendin-4) present in the venom of the Gila monster ( Heloderma suspectum ) and known to activate the receptor GLP-1
