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Description
Due to its pharmacokinetic profile, SEM presents a slightly different toxicity profile when compared to other GLP-1 receptor agonists, such as less frequent injection site effects and hypoglycemic risk (that can further increase when associated with insulin or sulfonylureas), but also more frequent vomiting [9]

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Most side effects peak during the first 90 days of treatment and then improve once the patient is on a stable, maintenance dose

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As most discontinuations occurred during the rapid dose-escalation period of treatment, slower up-titration of dose may counter these
