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The prevalence of HFpEF is rising, increasing from 33 to 39% between 2005 and 2010, with projections suggesting it will soon become the most common form of HF [5, 6]

10.1055/s-0031-1271777

Lean muscle mass: Weight loss with medicines of this class can include some loss of lean muscle mass alongside fat mass

These improvements were defined as "a drop in estimated glomerular filtration rate -- a measure of how much blood the kidneys filter clean every minute -- of at least 50%," according to the news release

The observations in SUSTAIN-6 are predictable, given that intensified versus conventional insulin therapy is well known to have the capacity to precipitate initial worsening of retinopathy in patients with T2D with advanced preexisting retinopathy, as shown in the Diabetes Control and Complications Trial (82)