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Interested in weight-loss medication
Other concerns about the long-term impacts of GLP-1RAs include the effects on body composition during use and weight regain following cessation
However, maintaining the lost weight requires ongoing adherence to Semaglutide GLP-1 therapy and lifestyle interventions
In Cleveland Clinic's 2025 analysis of real-world use, semaglutide 2.4 mg produced mean weight loss of approximately 14.1% at one year versus the ~15% trial number, and tirzepatide produced approximately 16.5% versus the 22% trial number
