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Even though this phenomenon has not been fully understood in the context of the possible exacerbation of pro-depressive changes by GLP-1RA administration, it certainly requires careful investigation before the potential introduction of these compounds to the clinic for the treatment of mood disorders in the future

Lower cravings They act on the brains appetite centres, reducing the urge to snack or overeat

[DOI] [PubMed] [Google Scholar] 116.Pillai P and Modarressi T, GLP1RAs in Clinical Practice: Therapeutic Advances and Safety Perspectives, 2024, 117.Kosiborod MN, Abildstrom SZ, Borlaug BA, et al

The effects of puerarin on autophagy through regulating of the PERK/eIF2/ATF4 signaling pathway influences renal function in diabetic nephropathy

Clinical trial outcomes (15% weight loss for Wegovy, 20% for Zepbound) are from studies of FDA-approved products under controlled conditions - they don't predict compounded product results or any individual's outcome