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The additive insulinotropic effect of GIP combined with GLP-1 results from direct beta-cell stimulation and enhancement of alpha-to-beta cell paracrine communication, with GIP contributing substantially to postprandial insulin secretion [30,31]

In a paper published in 1982, they showed that the glucagon precursor gene actually contains the code for three peptides: glucagon and two new hormones that are expressed in the gut

Survodutide is a dual GLP-1/glucagon receptor agonist showing promising results in clinical trials

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Other important contributing factors are eating disorders and depression, which are more common in patients with T1D compared to the overall population ( Figure 1 Obesity increases the risk of obesity-related as well as diabetes-related complications in patients with T1D, including micro- and macrovascular complications, various types of cancer, and overall mortality ( Figure 1 )