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Diana Mesa, RDN, LDN, CDCES, founder of En La Mesa Nutrition, agrees, adding that Berberine does have some similarities [to GLP-1 RA medications] in that it can trigger the pancreas to release insulin and helps make cells more sensitive to the effect of insulin, which is a characteristic similar to what Metformin [another prescription medication prescribed to treat type 2 diabetes and other off-label conditions] does. Still, she notes that its unclear whether or not Berberine has any appetite-suppressing effects like Ozempic and similar medications

Using proper reconstitution techniques and sourcing from reputable compounding pharmacies helps ensure equivalent safety

In 2022, the company that owns the patent of Eriomin funded a small clinical trial involving 45 people, concluding that those who took it over a 12-week period had lower blood glucose and higher GLP-1 than those who took a placebo

PlexusDx also offers GLP-Squared (a compounded dual-agent injection starting at $249/mo) and oral formulations for patients seeking alternatives to injections