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Even though semaglutide may not act directly on the uterus or menstrual hormones, the effects of weight loss, stress, and changes in how the body uses other drugs can play a role

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1 , 2 The rapid clinical adoption of these and other incretinmimetic drugs (IMDs) for obesity treatment has outpaced the ability of professional medical societies to update clinical practice guidelines

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4 As the first late-breaking clinical trial presented at the 2023 ESC Congress, Mikhail Kosiborod, MD, FACC , presented the initial results of STEP-HFpEF, a double-blind, placebo-controlled trial conducted at 96 sites globally, randomizing 529 people with obesity-phenotype HFpEF and without diabetes (56.1% women, median age 69 years) to semaglutide 2.4 mg vs

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