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Writingreview, and editing: Mojca Jensterle, pela Volanek, Andrijana Koceva, Emir Muzurovi and Andrej Jane

However, many users challenged this notion

Due to greater observed WL, Sema is more cost effective per unit WL whild Lira is better tolerated

The reduced risk of several CNS disorders were estimated by hazard ratios and they were modestly decreased for alcohol use disorder, cannabis use disorder, stimulant use disorder, opioid use disorder, suicidal ideation of self-injury, bulimia, schizophrenia, seizures and neurocognitive disorders

Some research suggests potential direct effects on hepatic lipid metabolism and lipoprotein synthesis, though these mechanisms require further investigation